PROSTAGLANDIN A(1) INHIBITS REPLICATION OF CLASSICAL SWINE FEVER VIRUS

Authors
FREITAS TRP CALDAS LA REBELLO MA
Citation
Trp. Freitas et al., PROSTAGLANDIN A(1) INHIBITS REPLICATION OF CLASSICAL SWINE FEVER VIRUS, Memorias do Instituto Oswaldo Cruz, 93(6), 1998, pp. 815-818
Citations number
22
Categorie Soggetti
Tropical Medicine",Parasitiology
Journal title
Memorias do Instituto Oswaldo Cruz → ACNP
ISSN journal
00740276
Volume
93
Issue
6
Year of publication
1998
Pages
815 - 818
Database
ISI
SICI code
0074-0276(1998)93:6<815:PAIROC>2.0.ZU;2-N
Abstract
Prostaglandins (Pgs) have been shown to inhibit the replication of sev eral DNA and RNA viruses. Here we report the effect of prostaglandin ( PgA(1)) on the multiplication of a positive strand RNA virus, Classica l Swine Fever Virus (CSFV) in PK15 cells. PgA(1) was found to inhibit the multiplication of CSFV. At a concentration of 5 mu g/ml, which was nontoxic to the cells, PgA(1) inhibitis virus production in 99%. In P gA(1) treated cells the size and number of characteristic Classical Sw ine Fever focus decreased in amount.