REVERSED END-DIASTOLIC UMBILICAL FLOW IN A FIRST-TRIMESTER FETUS WITHCONGENITAL HEART-DISEASE

Citation
A. Borrell et al., REVERSED END-DIASTOLIC UMBILICAL FLOW IN A FIRST-TRIMESTER FETUS WITHCONGENITAL HEART-DISEASE, Prenatal diagnosis, 18(10), 1998, pp. 1001-1005
Citations number
14
Categorie Soggetti
Genetics & Heredity","Obsetric & Gynecology
Journal title
ISSN journal
01973851
Volume
18
Issue
10
Year of publication
1998
Pages
1001 - 1005
Database
ISI
SICI code
0197-3851(1998)18:10<1001:REUFIA>2.0.ZU;2-O
Abstract
Reversed end-diastolic umbilical artery velocities and a reduced chori onic sac were first seen at 10 weeks in a pregnancy subsequently showi ng a normal male karyotype on chorionic villi. Four weeks later Dopple r studies demonstrated normal umbilical artery waveforms. At 20 weeks, ultrasound examination of the fetus revealed a mild pericardic effusi on, hypoplastic right heart with hypertrophic myocardium and a single umbilical artery, suggesting pulmonary atresia. After neonatal death, pathological studies confirmed pulmonary atresia. This case suggests t hat reversed end-diastolic umbilical flow in the first trimester may i dentify a subgroup of fetuses with a lethal abnormality (heart defect, severe intra-uterine retardation, aneuploidy or others). (C) 1998 Joh n Wiley & Sons, Ltd.