SCHWANGERSCHAFTS PROTEIN-1 (SP1) ADDS LITTLE TO THE AGE-RELATED DETECTION OF FETAL DOWN-SYNDROME IN THE FIRST-TRIMESTER OF PREGNANCY

Authors
KORNMAN LH MORSSINK LP TENHOOR KA DEWOLF BTHM KLOOSTERMAN MD BEEKHUIS JR MANTINGH A
Citation
Lh. Kornman et al., SCHWANGERSCHAFTS PROTEIN-1 (SP1) ADDS LITTLE TO THE AGE-RELATED DETECTION OF FETAL DOWN-SYNDROME IN THE FIRST-TRIMESTER OF PREGNANCY, Prenatal diagnosis, 18(10), 1998, pp. 1086-1090
Citations number
14
Categorie Soggetti
Genetics & Heredity","Obsetric & Gynecology
Journal title
Prenatal diagnosis → ACNP
ISSN journal
01973851
Volume
18
Issue
10
Year of publication
1998
Pages
1086 - 1090
Database
ISI
SICI code
0197-3851(1998)18:10<1086:SP(ALT>2.0.ZU;2-L
Abstract
Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our st udy compared SP1 levels in 15 pregnancies with a Down syndrome fetus a nd 97 matched controls. Although the median MoM in Down syndrome pregn ancies (0.49) was lower than in controls, its use as a marker added ve ry little to the detection rate above the maternal age alone. (C) 1998 John Wiley & Sons, Ltd.