A penalized latent class model for ordinal data

Citation
M. Desantis, Stacia et al., A penalized latent class model for ordinal data, Biostatistics (Oxford. Print) , 9(2), 2008, pp. 249-262
ISSN journal
14654644
Volume
9
Issue
2
Year of publication
2008
Pages
249 - 262
Database
ACNP
SICI code
Abstract
Latent class models provide a useful framework for clustering observations based on several features.Application of latent class methodology to correlated, high-dimensional ordinal data poses many challenges.Unconstrained analyses may not result in an estimable model.Thus, information contained in ordinal variables may not be fully exploited by researchers.We develop a penalized latent class model to facilitate analysis of high-dimensional ordinal data.By stabilizing maximum likelihood estimation, we are able to fit an ordinal latent class model that would otherwise not be identifiable without application of strict constraints.We illustrate our methodology in a study of schwannoma, a peripheral nerve sheath tumor, that included 3 clinical subtypes and 23 ordinal histological measures.