H. Zwinderman, Aeilko et al., Statistical models for quantifying diagnostic accuracy with multiple lesions per patient, Biostatistics (Oxford. Print) , 9(3), 2008, pp. 513-522
We propose random-effects models to summarize and quantify the accuracy of the diagnosis of multiple lesions on a single image without assuming independence between lesions.The number of false-positive lesions was assumed to be distributed as a Poisson mixture, and the proportion of true-positive lesions was assumed to be distributed as a binomial mixture.We considered univariate and bivariate, both parametric and nonparametric mixture models.We applied our tools to simulated data and data of a study assessing diagnostic accuracy of virtual colonography with computed tomography in 200 patients suspected of having one or more polyps.