PURE ALEXIA AND WORD-MEANING DEAFNESS IN A PATIENT WITH MULTIPLE-SCLEROSIS

Objective: To describe pure alexia and auditory comprehension problems in a young woman with multiple sclerosis (MS). Patient: A 33-year-old woman with MS who complained of difficulties in reading and comprehen ding spoken language was referred for a neuropsychological examination . Reading difficulties were confirmed and most of the reading errors w ere additions, omissions, and substitutions of single letters. While t he patient reported that the letters seemed to disappear before her ey es, no general problems with visual attention, visual discrimination, or scanning were detected. No difficulties with spelling were reported . The auditory comprehension deficit is interpreted as a form of a sem antic access disorder and is not due to generalized slowing in informa tion processing or conceptual disintegration. Conclusions: Pure alexia is unusual in MS and to our knowledge only 1 other case has been repo rted (in Japanese). Memory impairments and slowed information processi ng are probably the most frequent cognitive sequelae of the disease an d, consequently, the literature is biased toward the study of those co gnitive domains. However, given the wide distribution of sclerotic pla ques in MS, it could be argued that we should expect some variability of cognitive changes in MS. Striking deficits as seen in this patient should make us more sensitive to this possibility.