SUBSEQUENT REPRODUCTIVE EXPERIENCE AFTER TREATMENT FOR GESTATIONAL TROPHOBLASTIC DISEASE

Purpose, The purpose of this study was to evaluate reproductive perfor mance of patients with gestational trophoblastic disease (GTD) after c ompletion of treatment and follow-up periods. Patients and methods. Su bjects comprised 115 patients who became; pregnant after having been j udged completely cured after a follow-up period of at least 1 year. Th ere were 77 hydatidiform-mole patients who had a natural cure and 38 g estational trophoblastic tumor patients who were cured after chemother apy. We studied these patients with respect to parameters concerning p regnancy outcome. Results. Average age at first pregnancy was 28.0 and average number of past deliveries was 1.3, After a 1-year contracepti on period, the average time to the next pregnancy was 0.8 year, with 5 9 of 115 (51.3%) women becoming pregnant within 1 year after pregnancy was permitted and 98 women (85.2%) conceiving within 3 years. Results of the pregnancies after cure of GTD did not deviate from normal rang es in separated analyses of complete mole (CM), partial mole (PM), and gestational trophoblastic tumor. Rate of repeat mole was found to be high, occurring in 5 of 115 (4.3%) cases. Rates of antepartum and post partum complications did not deviate from normal ranges, and there was nothing peculiar about the neonatal sex and weight. Conclusion. GTD a nd chemotherapy rarely affect later pregnancies; however, the rate of repeat mole is relatively high. (C) 1998 Academic Press.