SYNTHESIS OF ANTIRHEUMATIC AGENT EPOXYQUINOMICIN-B

Authors
MATSUMOTO N IINUMA H SAWA T TAKEUCHI T
Citation
N. Matsumoto et al., SYNTHESIS OF ANTIRHEUMATIC AGENT EPOXYQUINOMICIN-B, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 2945-2948
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
21
Year of publication
1998
Pages
2945 - 2948
Database
ISI
SICI code
0960-894X(1998)8:21<2945:SOAAE>2.0.ZU;2-R
Abstract
Anti-rheumatic agent (+/-)-epoxyquinomicin B was synthesized for a 22% overall yield in eight steps from commercially available 3-hydroxy-4- nitrobenzaldehyde via the intermediate quinone 6 prepared by selective phenol oxidation of 5 by use of Fremy's salt as the key step. (C) 199 8 Elsevier Science Ltd. All rights reserved.