RATIONAL DESIGN OF A NEW SERIES OF MIXED ANTI-HIV PRONUCLEOTIDES

Authors
SCHLIENGER N BELTRAN T PERIGAUD C LEFEBVRE I POMPON A AUBERTIN AM GOSSELIN G IMBACH JL
Citation
N. Schlienger et al., RATIONAL DESIGN OF A NEW SERIES OF MIXED ANTI-HIV PRONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3003-3006
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
21
Year of publication
1998
Pages
3003 - 3006
Database
ISI
SICI code
0960-894X(1998)8:21<3003:RDOANS>2.0.ZU;2-8
Abstract
MonoSATE aryl phosphotriesters of AZT are able to deliver intracellula rly the corresponding 5'-mononucleotide. This process requires activat ion by an esterase followed by a phosphodiesterase. This finding opens the way to the design of hew pronucleotide series, (C) 1998 Elsevier Science Ltd. All rights reserved.