TRIPLE-HELIX STABILIZATION PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 8-AMINO-2'-DEOXYGUANOSINE

Authors
GARCIA RG BACHI A ERITJA R LUQUE FJ OROZCO M
Citation
Rg. Garcia et al., TRIPLE-HELIX STABILIZATION PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 8-AMINO-2'-DEOXYGUANOSINE, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3011-3016
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
21
Year of publication
1998
Pages
3011 - 3016
Database
ISI
SICI code
0960-894X(1998)8:21<3011:TSPOOC>2.0.ZU;2-1
Abstract
Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine wit h cytosine in the gase phase shows a strong stabilization of the 8-ami noguanine cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosin e confirm the triple helix stabilization properties of 8-aminoguanine. (C) 1998 Elsevier Science Ltd. Ail rights reserved.