R. Antunes et al., NEW PHTHALIMIDE DERIVATIVES WITH POTENT ANALGESIC ACTIVITY - II, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3071-3076
Seven new phthalimide derivatives (9a similar to g) with 1,2,4-oxadiaz
ol-5-yl methyl group attached to nitrogen have been synthesized from N
-phthaloylglycine 6 and arylamidoximes 7a similar to g. All of these s
howed potent analgesic effect with acetic acid induced ''writhing'' te
st in mice. One of the better compounds (ID50 = 2.2 mg/Kg ip) has been
found to be 9a which also demonstrates analgesic activity against inf
lammatory pain. (C) 1998 Elsevier Science Ltd. All rights reserved.