FACILE AND IMPROVED SYNTHESIS OF 4-BETA-AMINOPODOPHYLLOTOXIN CONGENERS

Authors
KAMAL A GAYATRI NL RAO NV
Citation
A. Kamal et al., FACILE AND IMPROVED SYNTHESIS OF 4-BETA-AMINOPODOPHYLLOTOXIN CONGENERS, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3097-3100
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
21
Year of publication
1998
Pages
3097 - 3100
Database
ISI
SICI code
0960-894X(1998)8:21<3097:FAISO4>2.0.ZU;2-L
Abstract
An efficient synthesis of 4 beta-aminopodophyllotoxin from 4 beta-brom opodophyllotoxin using ammonia, and also a facile synthesis of 4 beta- amino-4'-O-demethylpodophyllotoxin from 4 beta-azidopodophyllotoxin by simultaneous azido reduction and selective demethylation at 4'-positi on employing chlorotrimethylsilane and sodium iodide, has been describ ed. These are potential precursors for the various 4 beta-amino analog s of podophyllotoxin possessing DNA topoisomerase II inhibition activi ty. (C) 1998 Elsevier Science Ltd. All rights reserved.