STRUCTURAL DETERMINANTS OF SUBSTRATES AND INHIBITORS - PROBING GLUTAMATE TRANSPORTERS WITH 2,4-METHANOPYRROLIDINE-2,4-DICARBOXYLATE

Authors
ESSLINGER CS KOCH HP KAVANAUGH MP PHILIPS DP CHAMBERLIN AR THOMPSON CM BRIDGES RJ
Citation
Cs. Esslinger et al., STRUCTURAL DETERMINANTS OF SUBSTRATES AND INHIBITORS - PROBING GLUTAMATE TRANSPORTERS WITH 2,4-METHANOPYRROLIDINE-2,4-DICARBOXYLATE, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3101-3106
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
21
Year of publication
1998
Pages
3101 - 3106
Database
ISI
SICI code
0960-894X(1998)8:21<3101:SDOSAI>2.0.ZU;2-Y
Abstract
Using an intramolecular [2+2] photocyclization, 2,4-methanopynolidine- 2,4-dicarboxylate was prepared as a conformationally locked analogue o f glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that d ifferentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter. (C) 1998 Elsevier Science Ltd . All rights reserved.