A SIMPLE AND EFFICIENT NEW APPROACH TO THE TOTAL SYNTHESIS OF (+ -)-4-AMINO-3-(4-CHLOROPHENYL)-BUTYRIC ACID (BACLOFEN)/

Authors
COELHO F DEAZEVEDO MBM BOSCHIERO R RESENDE P
Citation
F. Coelho et al., A SIMPLE AND EFFICIENT NEW APPROACH TO THE TOTAL SYNTHESIS OF (+ -)-4-AMINO-3-(4-CHLOROPHENYL)-BUTYRIC ACID (BACLOFEN)/, Synthetic communications, 27(14), 1997, pp. 2455-2465
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
14
Year of publication
1997
Pages
2455 - 2465
Database
ISI
SICI code
0039-7911(1997)27:14<2455:ASAENA>2.0.ZU;2-J
Abstract
Based on the utilization of a [2+2] cycloaddition reaction between dic hloroketene and an appropriated olefin as a key step, we describe a ne w and simple four step approach to the total synthesis of (+/-)-4-amin o-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABA(B) agon ist used as antispastic agent.