CHROMATOGRAPHIC-SEPARATION OF BISOPROLOL, LABETALOL AND PROPAFENONE IN THE FORM OF DABSYL DERIVATIVES

Authors
WITEK A HOPKALA H PRZYBOROWSKI L
Citation
A. Witek et al., CHROMATOGRAPHIC-SEPARATION OF BISOPROLOL, LABETALOL AND PROPAFENONE IN THE FORM OF DABSYL DERIVATIVES, Chemia Analityczna, 43(5), 1998, pp. 817-822
Citations number
35
Categorie Soggetti
Chemistry Analytical
Journal title
Chemia Analityczna → ACNP
ISSN journal
00092223
Volume
43
Issue
5
Year of publication
1998
Pages
817 - 822
Database
ISI
SICI code
0009-2223(1998)43:5<817:COBLAP>2.0.ZU;2-C
Abstract
Thin-Layer chromatography application for the separation and identific ation of bisoprolol, tabetalol and propafenone as their dabsyl derivat ives is described. These compounds were converted to the chromophoric dabsyl derivatives and chromatographed on silica gel and aluminium oxi de plates by ascending development, using various solvent systems. The detection limits of dabsyl derivatives on aluminium oxide plates were 2.5x10(-11), 2.5x10(-10) and 1x10(-9) mol/spot for labetalol, propafe none and bisoprolol, respectively.