ENZYME-CATALYZED FORMATION OF (S)-CYANOHYDRINS DERIVED FROM ALDEHYDESAND KETONES IN A BIPHASIC SOLVENT SYSTEM

Authors
GRIENGL H KLEMPIER N POCHLAUER P SCHMIDT M SHI NY ZABELINSKAJAMACKOVA AA
Citation
H. Griengl et al., ENZYME-CATALYZED FORMATION OF (S)-CYANOHYDRINS DERIVED FROM ALDEHYDESAND KETONES IN A BIPHASIC SOLVENT SYSTEM, Tetrahedron, 54(48), 1998, pp. 14477-14486
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
48
Year of publication
1998
Pages
14477 - 14486
Database
ISI
SICI code
0040-4020(1998)54:48<14477:EFO(DF>2.0.ZU;2-2
Abstract
By employing a vigorously stirred two phase system aqueous buffer/orga nic solvent and using the hydroxynitrile lyase from Hevea brasiliensis as biocatalyst enantiopure (S)-cyanohydrins from aliphatic, unsaturat ed, aromatic and heteroaromatic aldehydes and methyl alkyl and methyl phenyl ketones are obtained in high yield and in general 98-99% enanti omeric excess. (C) 1998 Elsevier Science Ltd. AII rights reserved.