IFOSFAMIDE AND VINORELBINE - AN ACTIVE REGIMEN FOR PATIENTS WITH RELAPSED OR REFRACTORY HODGKINS-DISEASE

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide ( 3000 mg/m(2)/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m(2), i.v. days 1 and 5) with mesna uroprotection a nd G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an o verall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.