SEMIPARAMETRIC EFFICIENT ESTIMATION FOR SHARED-FRAILTY MODELS WITH DOUBLY-CENSORED CLUSTERED DATA

Citation
Yu-ru Su et Jane-ling Wang, SEMIPARAMETRIC EFFICIENT ESTIMATION FOR SHARED-FRAILTY MODELS WITH DOUBLY-CENSORED CLUSTERED DATA, Annals of statistics , 44(3), 2016, pp. 1298-1331
Journal title
ISSN journal
00905364
Volume
44
Issue
3
Year of publication
2016
Pages
1298 - 1331
Database
ACNP
SICI code
Abstract
In this paper, we investigate frailty models for clustered survival data that are subject to both left-and right-censoring, termed "doubly-censored data". This model extends current survival literature by broadening the application of frailty models from right-censoring to a more complicated situation with additional left-censoring. Our approach is motivated by a recent Hepatitis study where the sample consists of families. We adopt a likelihood approach that aims at the nonparametric maximum likelihood estimators (NPMLE). A new algorithm is proposed, which not only works well for clustered data but also improve over existing algorithm for independent and doubly-censored data, a special case when the frailty variable is a constant equal to one. This special case is well known to be a computational challenge due to the left-censoring feature of the data. The new algorithm not only resolves this challenge but also accommodates the additional frailty variable effectively. Asymptotic properties of the NPMLE are established along with semiparametric efficiency of the NPMLE for the finite-dimensional parameters. The consistency of Bootstrap estimators for the standard errors of the NPMLE is also discussed. We conducted some simulations to illustrate the numerical performance and robustness of the proposed algorithm, which is also applied to the Hepatitis data.