MECHANISMS MEDIATING MULTIPLE PHYSIOLOGICAL-RESPONSES TO GONADOTROPIN-RELEASING-HORMONE

A central question in endocrinology is how a single ligand interacting with a single receptor can mediate multiple responses. GnRH interacti on with receptor offers a prime example, leading to the regulation of synthesis and release of at least three molecules, regulation of targe t cell responsiveness and receptor number. The present study suggests a molecular model consistent with errant data that provides a mechanis m by which this may occur and, further, which allows for coordinate re gulation. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.