This paper deals with the Nash inequalities and the related ones for general symmetric forms which can be very much unbounded. Some sufficient conditions in terms of the isoperimetric inequalities and some necessary conditions for the inequalities are presented. The resulting conditions can be sharp qualitatively as illustrated by some examples. It turns out that for a probability measure, the Nash inequalities are much stronger than the Poincaré and the logarithmic Sobolev inequalities in the present context.