GENOMIC LOCALIZATION OF THE HUMAN GENE FOR KCNA10, A CGMP-ACTIVATED KCHANNEL

Potassium (K) channels are important components of virtually all cells , and they play critical roles in many cellular functions. KCNA10 repr esents a new class of K channel specifically regulated by cGMP and pos tulated to mediate the effects of substances that increase intracellul ar cGMP. Since KCNA10 has the potential to be useful in candidate gene analysis of inherited diseases, the human gene for KCNA10 was charact erized. Fluorescence in situ hybridization indicates that human KCNA10 maps to chromosome I at p13.1 --> p22.1. Finer mapping of the gene wa s achieved by PCR of a set of CEPH YAC clones that spanned the region of interest. We found that YAC 818b9 contains human KCNA10. These data indicate human KCNA10 maps to 1p13.1 and resides within the genetic i nterval defined by microsatellite loci D1S2809 and D1S2726. That regio n of chromosome 1 contains another K channel gene, KCNA3. (C) 1997 Aca demic Press.