MAPPING OF THE HUMAN HPC-1 SYNTAXIN 1A GENE (STX1A) TO CHROMOSOME-7 BAND Q11.2/

We previously described the cDNA sequence of HPC-1/syntaxin 1A (HGMW-a pproved symbol STX1A) from rat and bovine brains. HPC-1/syntaxin 1A be longs to the syntaxin family and is apparently involved in intracellul ar membrane transport and the exocytosis of neurotransmitters. In this study, we isolated the cDNA and the genomic DNA clone for human HPC-1 /syntaxin 1A and carried out gene mapping. Polymerase chain reaction a nalysis of human/rodent somatic cell hybrid panels and fluorescence in situ hybridization analysis using a genomic DNA clone provided eviden ce that the gene for human HPC-1/syntaxin 1A maps to chromosome region 7q11.2. (C) 1997 Academic Press.