ENANTIOSELECTIVE SYNTHESIS OF ALPHA-HYDROXY PHOSPHONATES VIA OXIDATION WITH (CAMPHORSULFONYL)OXAZIRIDINES

Authors
POGATCHNIK DM WIEMER DF
Citation
Dm. Pogatchnik et Df. Wiemer, ENANTIOSELECTIVE SYNTHESIS OF ALPHA-HYDROXY PHOSPHONATES VIA OXIDATION WITH (CAMPHORSULFONYL)OXAZIRIDINES, Tetrahedron letters, 38(20), 1997, pp. 3495-3498
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
20
Year of publication
1997
Pages
3495 - 3498
Database
ISI
SICI code
0040-4039(1997)38:20<3495:ESOAPV>2.0.ZU;2-7
Abstract
Reaction of phosphonate anions with enantiomerically pure (camphorsulf onyl)oxaziridines results in formation of nonracemic alpha-hydroxy pho sphonates. This enantioselective hydroxylation methodology provides co nvenient access to optically active alpha-hydroxy phosphonates and the ir corresponding phosphonic acids. (C) 1997 Elsevier Science Ltd.