THE SYNTHESIS OF A NOVEL BENZODIAZOCINE VIA AN INTRAMOLECULAR STAUDINGER AZA-WITTIG CYCLIZATION/

Authors
ONEIL IA MURRAY CL POTTER AJ KALINDJIAN SB
Citation
Ia. Oneil et al., THE SYNTHESIS OF A NOVEL BENZODIAZOCINE VIA AN INTRAMOLECULAR STAUDINGER AZA-WITTIG CYCLIZATION/, Tetrahedron letters, 38(20), 1997, pp. 3609-3610
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
20
Year of publication
1997
Pages
3609 - 3610
Database
ISI
SICI code
0040-4039(1997)38:20<3609:TSOANB>2.0.ZU;2-1
Abstract
The novel pyrrolobenzodiazocine (1) has been prepared by an intramolec ular Staudinger/aza Wittig protocol from the precursor azido aldehyde (2) in a remarkable 93% yield. Aldehyde (2) was prepared by coupling p rotected homoprolinol with 2-azidobenzoic acid followed by deprotectio n and oxidation. (C) 1997 Elsevier Science Ltd.