D. Groshar et al., QUANTITATIVE SPET TC-99(M)-DMSA UPTAKE BY THE KIDNEYS - AGE-RELATED DECLINE IN HEALTHY-MALES, Nuclear medicine communications, 19(9), 1998, pp. 893-897
To evaluate if Tc-99(m)-dimercaptosuccinic acid (Tc-99(m)-DMSA) uptake
by the kidneys is related to age and creatinine clearance in males wi
th normal renal function, quantitative single photon emission tomograp
hy (SPET) of DMSA uptake by the kidneys was performed in 18 volunteers
aged 20-79 years. The quantitative uptake of DMSA in the right kidney
was 13.9 +/- 2.9% and in the left kidney 14.2 +/- 3.0%. There was no
statistically significant difference between left and right kidney upt
ake (t = 1.2, N.S.). Global kidney uptake (right + left) was 28.1 +/-
5.9%. There was a statistically significant age-related decline in glo
bal DMSA uptake. The estimated DMSA uptake (%) was given by -0.27 x ag
e + 42 (r =-0.87, P <0.001). A good correlation was found between crea
tinine clearance and global DMSA uptake (r = 0.87 y = 2.8x + 28.3, P <
0.001). The results suggest that normal values of DMSA uptake by the
kidneys are age-dependent. ((C) 1998 Lippincott Williams & Wilkins).