REPRODUCIBILITY OF TC-99(M)-MAG3 CLEARANCE IN NORMAL VOLUNTEERS WITH THE 2-SAMPLE METHOD - COMPARISON WITH I-131 OIH

The aim of this study was to evaluate the reproducibility of Tc-99(m)- mercaptoacetyltriglycine (Tc-99(m)-MAG3) clearance and to compare it w ith that of I-131-orthoiodohippurate (I-131-OIH), which is widely used in clinical practice. Twelve young healthy volunteers with a mean age of 23.4 years (range 19-28) were enrolled in the study. The investiga tions were repeated at an interval of 1 month under similar physiologi cal conditions. Each volunteer received a simultaneous injection of Tc -99(m)-MAG3 and I-131-OIH that was commercially available in an alread y labelled form. Blood samples were obtained at 44 and 104 min post-in jection. Clearance values were calculated using the two-sample method. The mean (+/- S.D.) change from the first to the second measurement w as -7.1 +/- 11.1% for Tc-99(m)-MAG3 and 1.7 +/- 13.6% for I-131- OIH. There were no significant differences between the first and the second measurements of Tc-99(m)-MAG3 and I-131-OIH clearance, respectively. Tc-99(m)-MAG3 clearance was shown to be very similar to that of I-131- OIH in healthy volunteers. ((C) 1998 Lippincott Williams & Wilkins).