PHOTOCHEMICALLY INDUCED FLUOROMETRIC DETECTION OF TIANEPTINE AND SOMEOF ITS METABOLITES - APPLICATION TO PHARMACEUTICAL PREPARATION

The photochemically induced fluorescence (PIF) properties of tianeptin e and some of its metabolites were investigated in acidic (pH 2.3) wat er-alcohol mixtures at room temperature. Two PIF methods were develope d, including bulk solution and flow injection analysis (FIA). Linear c alibration plots were established over a concentration range of more t han one order of magnitude. Limits of detection ranged from 15 ng ml(- 1) for FIA-PIF to 25 ng ml(-1) in bulk solution. The RSDs were between 3 and 5%. The PIF methods were applied to the determination of tianep tine in a pharmaceutical preparation with recoveries varying from 96 t o 106% in bulk solutions and from 98 to 106% for FIA-PIF.