MATERNAL SERUM CREATINE-KINASE DOES NOT PREDICT TUBAL PREGNANCY

Purpose: Our purpose was to validate prospectively the predictive valu e of maternal serum creatine kinase in the evaluation of ectopic pregn ancy. Methods: Fifty-one consecutive pregnant first-trimester patients who presented for suspected abnormal pregnancy were enrolled Maternal serum samples were obtained and assayed for creatine kinase. Patients were subsequently evaluated for abnormal pregnancy by serial quantita tive ACG levels, transvaginal ultrasonography, and surgery when approp riate. A receiver operating characteristic (ROC) curve was generated c omparing intrauterine to extrauterine (ectopic) pregnancy. Results: Of 51 patients, 18 had an ectopic pregnancy, 16 had a spontaneous aborti on, and 17 had an ongoing intrauterine pregnancy. The ROC curve reveal ed that maternal serum creatine kinase had no ability to predict ectop ic pregnancy.Conclusions: Maternal serum creatine kinase is not a reli able predictor of tubal pregnancy.