DEVELOPMENT OF A MULTIARRAY BIOSENSOR FOR DNA DIAGNOSTICS

This work involves the development and evaluation of a multiarray bios ensor for DNA diagnostics. The evaluation of various system components developed for the biosensor is discussed. The DNA probes labeled with visible and near infrared (NIR) dyes are evaluated. The detection sys tem uses a two-dimensional charge-coupled device (CCD). Examples of ap plication of gene probes in DNA hybridization experiments and in biome dical diagnosis (detection of the p53 cancer gene) are presented to il lustrate the usefulness and potential of the biosensor device.