SIGNIFICANT DECREASED INSULIN-SECRETION IN A DIABETIC PATIENT WITH CLINICALLY PROBABLE MULTIPLE-SCLEROSIS

A 39-year-old man with chief complaints of aphasia, disorientation and acalculia was admitted to our hospital. He was diagnosed as a clinica lly probable case of multiple sclerosis (MS) and his symptoms improved while on steroid pulse therapy. The patient had been diagnosed as hav ing diabetes mellitus 16 years before the onset of MS and his insulin secretion further decreased with time. Slight insulin resistance was o bserved during a euglycemic hyperinsulinemic clamp study, These result s suggested that this patient developed diabetes mellitus mainly due t o the decrease of insulin secretion.