SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IMAGE OF BENZODIAZEPINE RECEPTORS IN A PATIENT WITH CREUTZFELDT-JAKOB-DISEASE

A 50-year-old woman presented with progressive visual disturbance, ata xia, and dementia, The cerebral cortex became atrophic, as the disease progressed, and electroencephalography showed periodic synchronous di scharges. The patient's prion gene revealed a point mutation ((232)Met to Arg), and a diagnosis of Creutzfeldt-Jakob disease was made, Iomaz enil single-photon emission computed tomography (SPECT) was performed to assess neuronal degeneration, Accumulation of the tracer in the lat e images was severely decreased diffusely spread throughout the cerebr al cortex. Our experience with this case suggests that iomazenil SPECT is useful for detecting neuronal degeneration in Creutzfeldt-Jakob di sease.