SENSITIVITY AND SPECIFICITY OF SEVERAL IMMUNOCHEMICAL TESTS FOR COLORECTAL-CANCER

BACKGROUND/AIM: The purpose of this study was to evaluate the diagnost ic accuracy of new different immunochemical fecal occult blood tests f or colorectal cancer, including Iatro Hemcheck, Immudia-Hem Sp, LA Hem ochaser, Monohaem and OC-Hemodia. METHODOLOGY: Ninety-six patients wit h colorectal cancer and the same number of healthy controls served as subjects for the study. In this study, each subject received a set of five immunochemical tests over three consecutive days; and sensitiviti es and specificity of these tests were evaluated. RESULTS: Mean sensit ivity and specificity in a set of five immunochemical tests were 91.0% and 95.2%, respectively. Sensitivities and specificity of five differ ent immunochemical tests were calculated as 92.7% and 92.7% for Iatro- Hemcheck, 40.6% and 96.9% for Immudia-Hem Sp, 88.5% and 96.9% for LA H emochaser, 91.7% and 95.8% for Monohaem, and 91.7% and. 93.8% for OC-H emodia, respectively, showing no significant difference in sensitivity and specificity among five tests. CONCLUSIONS: These results suggest that immunochemical tests for fecal occult blood tests has high diagno stic validity for colorectal cancer. In addition, there is no signific ant difference in the degree of accuracy among the several types of im munochemical tests.