IDIOPATHIC THROMBOCYTOPENIA ASSOCIATED WITH WILSONS-DISEASE

We present the case of a 53 year-old patient with idiopathic thrombocy topenia associated with Wilson's disease. Idiopathic thrombocytopenia was diagnosed in August of 1994, and as the response to corticosteroid therapy was poor, the patient underwent a splenectomy in October of t he same year. A Liver biopsy, which was performed during the operation , showed Wilson's disease in the form of mild, chronic, active hepatit is. The serum ceruloplasmin was low, and the Kayser Fleischer's ring w as positive. MRI of the brain showed cortical reductive changes with a reas of copper accumulation in the white brain matter. An unusual pres entation of Wilson's disease associated with idiopathic thrombocytopen ia has not been published as of yet. The diagnosis of Wilson's disease was made at an advanced, adult age, which may implicate a heterozygou s genetic configuration.