Scanning probe microscopes (SPMs) are a family of related instruments
which can produce high-resolution images of structures at the molecula
r and atomic levels. Their main impact so far has been in surface scie
nce, but they also have tremendous potential for the study of biomolec
ules. In this article we will briefly introduce the properties and pri
nciples of these instruments, and then discuss a range of preliminary
studies from our laboratories in relation to future applications in ce
real science.