RNA EDITING - GETTING U INTO RNA

RNA editing in kinetoplastid protozoa remodels the sequences of mitoch ondrial pre-mRNAs by the precise insertion and deletion of uridylate r esidues. These sequence changes are directed by small trans-acting RNA s, termed guide RNAs. The basic mechanistic pathway by which edited RN A is generated has recently been elucidated using in vitro systems cap able of a full round of guide-RNA-directed editing.