Lipid oxidation is a process, which results in rancidity and deteriora
tion of fats posing a major problem in food industry and on biological
systems. Many synthetic antioxidants are used in food systems to inhi
bit lipid oxidation. However, the safety concerns about synthetic anti
oxidants have led to spurt of research on antioxidants from natural re
sources, particularly those derived from plant sources. Findings from
some such studies on potent aromatic plants having good antioxidant po
tentials should be pooled to be exploited in food as well as in biolog
ical system as a safe alternative to synthetic antioxidants. An attemp
t has been made in the present review to critically appraise the poten
tials and safety aspects of synthetic and natural antioxidants for use
in food systems.