THE STRUCTURE OF THE MOST STUDIED DNA FRAGMENT CHANGES UNDER THE INFLUENCE OF IONS - A NEW PACKING OF D(CGCGAATTCGCG)

Authors
LIU J MALININA L HUYNHDINH T SUBIRANA JA
Citation
J. Liu et al., THE STRUCTURE OF THE MOST STUDIED DNA FRAGMENT CHANGES UNDER THE INFLUENCE OF IONS - A NEW PACKING OF D(CGCGAATTCGCG), FEBS letters, 438(3), 1998, pp. 211-214
Citations number
18
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
438
Issue
3
Year of publication
1998
Pages
211 - 214
Database
ISI
SICI code
0014-5793(1998)438:3<211:TSOTMS>2.0.ZU;2-G
Abstract
The title oligonucleotide and many related dodecamers have been extens ively studied alone and as DNA-drug complexes, In practically all case s they were found to crystallize in the same space group, stabilized b y interactions among the terminal guanine bases. Here me report new pa cking interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodeca mers. (C) 1998 Federation of European Biochemical Societies.