MOLECULAR-RECOGNITION-DIRECTED SELF-ASSEMBLY OF PLEATED SHEETS FROM 2-AMINOPYRIMIDINE HYDROGEN-BONDING MOTIFS

The self-assembly of the ino-5,5'-(dialkylmethylidene)methylenedipyrim idine derivatives 3a-c allows for the molecular-recognition-directed g eneration of pleated sheets as revealed by X-rap crystallographic anal ysis. The data provide insight into the interplay of the different str uctural and interactional features of the molecular components in the generation of the supramolecular assembly. The introduction of the ada mantylidene group as in 3c leads to the dominance of the H-bonding fac tor and the resulting formation of a regular, fully interconnected arr ay of pleated sheet type. The results suggest further manipulation of the interplay of the different factors to induce the self-assembly of other supramolecular architectures.