BACTEREMIA AND FUNGEMIA IN PATIENTS WITH ADVANCED HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION IN TAIWAN

To understand the etiology and clinical outcome of bacterial and funga l sepsis in patients with advanced human immunodeficiency virus (HIV) infection in Taiwan, we conducted a prospective study of nonmycobacter ial bacteremia and fungemia in HN-infected patients with fever who wer e admitted to a university hospital in Taiwan during a 42-month period . Of 210 patients, 41 (19.5%) had a total of 52 episodes of sepsis due to nonmycobacterial bacteria or fungi, or both (15.5% of 336 episodes of fever). All but one patient had acquired immunodeficiency syndrome (AIDS), and the mean CD4 lymphocyte count was 29/mu L (range, 0-321/ mu L). A total of 57 pathogens (39 bacteria and 18 fungi) were isolate d from blood; polymicrobial sepsis due to both bacteria and fungi occu rred in four episodes. Nontyphoid Salmonello (NTS) nas the most common cause of community-acquired bacteremia (24/30, 80%). Staphylococcus a ureus bacteremia was diagnosed in three episodes while Streptococcus p neumoniae bacteremia was found in only one. Cryptococcus neoformans wa s the most common cause of fungemia and was responsible for 12 episode s, while fungemia due to Penicillium marneffei and Histoplasma capsula tum, two emerging fungi in Taiwan, were diagnosed in four cases and on e case, respectively. Nine episodes, eight of bacteremia and one of ca ndidemia, were nosocomial. The overall in-hospital mortality was 29%, and nosocomial sepsis was associated with a higher mortality rate (56% , p = 0.02). The mean duration of survival after recovery from initial sepsis was 426 days. We conclude that NTS bacteremia was the most com mon cause of sepsis in patients with advanced HIV infection in Taiwan and clinicians caring for such patients should watch for emerging fung al infections. Nosocomial sepsis was associated with a high mortality rate. The mean survival duration after recovery from sepsis of our pat ients was short.