CHROMOSOME LOCALIZATION AND GENOMIC STRUCTURE OF THE KISS-1 METASTASIS SUPPRESSOR GENE (KISS1)

The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1 ), a human malignant melanoma metastasis-suppressor gene, was recently published. In this report, we present a corrected genomic sequence, g enomic structure, and refined chromosomal location for KiSS-1. The gen omic organization of the sequence reveals a gene consisting of four ex ons. The first two exons are not translated; the third exon contains 3 8 5' noncoding bases followed by the translational start site and anot her 100 translated bases. The terminal exon contains a further 332 tra nslated bases, the translational stop codon, and the polyadenylation s ignal The gene maps to chromosome 1q32 as determined by radiation hybr id mapping and FISH analysis, The relatively simple organization of th is gene will facilitate analyses for mutations and abnormal expression in human tumors. (C) 1998 Academic Press.