SOME EFFECTS OF PROPHYLACTIC ASPIRINS AND HEPARINS ON CONCURRENT ARTERIAL AND VENOUS THROMBOSIS IN THE SAME ANIMAL

The antithrombotic effect of unfractionated heparin (UFH), a low-molec ular weight heparin (LMWH), oral acetylsalicylic acid (ASA), intraveno us lysine-aspirin (L-ASA) and oral soluble aspirin (S-ASB) was measure d on platinum wire simultaneously in artery and vein, in groups of 12- 20 rats with concurrent untreated controls. Subcutaneous LMWH and intr avenous lysine-aspirin reduced mean thrombus weight by 33% and 19%, re spectively, in the artery only. Venous thrombosis was reduced 56% by o ral ASA and 26% by oral soluble aspirin. Other reductions did not reac h statistical significance. While thrombus deposition was induced by b oth 2 cm (upper site) and 1 cm (lower site) wires, the results obtaine d on the 2 cm wires in the upper vein and artery were more reliable. ( C) 1998 Elsevier Science Ltd.