r-scan statistics of a Poisson process with events transformed by duplications, deletions, and displacements

Citation
Chen, Chingfer et Karlin, Samuel, r-scan statistics of a Poisson process with events transformed by duplications, deletions, and displacements, Advances in applied probability , 39(2), 2007, pp. 799-825
ISSN journal
00018678
Volume
39
Issue
2
Year of publication
2007
Pages
799 - 825
Database
ACNP
SICI code
Abstract
A stochastic model of a dynamic marker array in which markers could disappear, duplicate, and move relative to its original position is constructed to reflect on the nature of long DNA sequences. The sequence changes of deletions, duplications, and displacements follow the stochastic rules: (i) the original distribution of the marker array {., X.2, X.1, X0, X1, X2, .} is a Poisson process on the real line; (ii) each marker is replicated l times; replication or loss of marker points occur independently; (iii) each replicated point is independently and randomly displaced by an amount Y relative to its original position, with the Y displacements sampled from a continuous density g(y). Limiting distributions for the maximal and minimal statistics of the r-scan lengths (collection of distances between r + 1 successive markers) for the l-shift model are derived with the aid of the Chen-Stein method and properties of Poisson processes.