FOURIER-ANALYSIS OF NUCLEOTIDE-SEQUENCES - PERIODICITIES IN ESCHERICHIA-COLI PROMOTER SEQUENCES

Fourier spectra of E.coli promoter DNA sequences have been obtained. T he periodical structure of individual promoter sequences is characteri zed. E.coli promoter sequences are classified according to their Fouri er spectra using three feature sets: 1- the number of peaks in Fourier spectra; 2 - values of power spectra for promoter primary structures and their similarity with physical periodicities in the backbone of po lynucleotide; 3 - the presence of blocks made of equal mucleotides. Th e comparison of Fourier spectra of promoter sequences and correspondin g genes is provided. The conclusion that different ways of stabilizati on of promoter secondary structure in the case of different primacy st ructure periodicities is drawn. The intermittence of AT- and GC- block s, and variety of Fourier spectra mean DNA hydrate shell in DNA promot ers is non-contiguous and non-stable at junction points. Characteristi c features of prokaryotic promoters Fourier spectra differ from human promoters.