EFFECT OF ANTIOXIDANT (UBIQUINONE Q-9) AN D CHRONIC LOW-DOSE RADIATION ON THE CHROMATIN STRUCTURE AND PROLIFERATION IN RAT T-LYMPHOCYTES

Authors
NOVOSELOVA EG GORDON RY SEMILETOVA NV KARNAUKHOV VN
Citation
Eg. Novoselova et al., EFFECT OF ANTIOXIDANT (UBIQUINONE Q-9) AN D CHRONIC LOW-DOSE RADIATION ON THE CHROMATIN STRUCTURE AND PROLIFERATION IN RAT T-LYMPHOCYTES, Biofizika, 42(2), 1997, pp. 459-465
Citations number
17
Categorie Soggetti
Biophysics
Journal title
Biofizika → ACNP
ISSN journal
00063029
Volume
42
Issue
2
Year of publication
1997
Pages
459 - 465
Database
ISI
SICI code
0006-3029(1997)42:2<459:EOA(QA>2.0.ZU;2-V
Abstract
We have demonstrated the protective effect of natural antioxidant coen zyme Q-9 on the T-cell proliferative capacity and chromosomal DNA stat e under low dose chronic irradiation. The DNA-staining fluorescent dye Hoechst-33258 and acridin orange were to observed the nuclear morphol ogy changes in T-lymphocytes. Ubiquinone diet partially restored the d ecreasing in immune response and the luminescence intensity of DNA-Hoe chst-33258 complex in T-cells of low dose irradiated rats.