HYDROPHOBIC AND HYDROPHILIC FE2-OXIDE IN MOUSE ORGANISM( COMPLEXE S WITH DERIVATIVES OF DITHIOCARBAMATE AS A TRAPS OF NITRIC)

It has been shown by using EPR method that hydrophobic complexes Fe2+- diethyldithiocarbamate (DETC) act more efficiently as a selective trap s of nitric oxide (NO) in mice organisms than hydrophylic complexes Fe 2+-N-methyl-D-glutamildithiocarbamate (MGD). This difference seemed to be due to higher stability of paramagnetic mononitrosyl iron complexe s with DETC (MNIC-DETC) formed in vivo in animal tissues in a result o f NO binding with Fe2+-DETC complexes. Analogeous complexes MNIC-MGD a ppeared a blood were oxidized to diamagnetic, EPR silent form. The lat ter was also detected in mouse urine especially for animals which were pretreated with bacterial lipopolysaccharide inducing increased NO ge neration in mice organisms. Nitrogen dioxide or peroxynitrite formed e ndogeneous NO were suggested to be the agents which oxidized MNIC-MGD by reversible way in mice organisms.