GENOTOXICITY FROM DOMESTIC USE OF ORGANOPHOSPHATE PESTICIDES

Citation
Ad. Lieberman et al., GENOTOXICITY FROM DOMESTIC USE OF ORGANOPHOSPHATE PESTICIDES, Journal of occupational and environmental medicine, 40(11), 1998, pp. 954-957
Citations number
20
Categorie Soggetti
Public, Environmental & Occupation Heath
ISSN journal
10762752
Volume
40
Issue
11
Year of publication
1998
Pages
954 - 957
Database
ISI
SICI code
1076-2752(1998)40:11<954:GFDUOO>2.0.ZU;2-S
Abstract
This report describes the types of chromosome damage in peripheral blo od found in patients exposed to domestic application of organophosphat e pesticides. These changes serve as a biomarker of cumulative toxic e xposure. Susceptible individuals show DNA damage as chromosome alterat ions. The importance of these findings is that the apparent genotoxic changes occurred from domestic application of two of the commonly used organophosphate pesticides in America and adds one more adverse poten tial effect from these hazardous chemicals, Peripheral blood from eigh t patients exposed to the domestic spraying of organo-phosphate pestic ides was cultured and the chromosomes photographed. The types of chrom osome alterations seen included chromatid and chromosome breaks, singl e and double minutes, dicentrics, rings, translocations, exchanges (in cluding sister chromatid), and endoreduplications. Our findings suppor t previous findings that organophosphate pesticides have genotoxic eff ects even at domestically sprayed levels.