ISOLATION OF N-(2-METHYL-3-OXODECANOYL)PYRROLE AND N-(2-METHYL-3-OXODEC-8-ENOYL)PYRROLE, 2 NEW NATURAL-PRODUCTS FROM PENICILLIUM-BREVICOMPACTUM, AND SYNTHESIS OF ANALOGS WITH INSECTICIDAL AND FUNGICIDAL ACTIVITY

Two new natural products have been isolated from culture broth of Peni cillium brevicompactum Dierckx. The structures have be en assigned as N-(2-methyl-3-oxodecanoyl)pyrrole and N-(2-methyl-3-oxodec-8-enoyl)pyr role on the basis of spectral data. Synthesis of analogues has been ca rried out by acylation of the pyrrole ring at Ct with different acylat ed Meldrum's acids. Two analogues (6b and 7b) have shown interesting i nsecticidal activities, and three other ones (6a, 6c, and 7a) have exh ibited significant broad-spectrum fungicidal activities. These synthet ic products might be considered as a starting point in the search for new pesticides.