CONFORMATIONALLY DEFINED PIPERAZINE BIS(N-OXIDES) BEARING AMINO-ACID DERIVED SIDE-CHAINS

Authors
ONEIL IA POTTER AJ SOUTHERN JM STEINER A BARKLEY JV
Citation
Ia. Oneil et al., CONFORMATIONALLY DEFINED PIPERAZINE BIS(N-OXIDES) BEARING AMINO-ACID DERIVED SIDE-CHAINS, Chemical communications, (22), 1998, pp. 2511-2512
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
22
Year of publication
1998
Pages
2511 - 2512
Database
ISI
SICI code
1359-7345(1998):22<2511:CDPBBA>2.0.ZU;2-5
Abstract
The preparation of a number of piperazine derivatives bearing amino ac id substituents on the nitrogen is described; these compounds undergo oxidation with MCPBA to yield bis(N-oxides) in which both oxygen atoms are axially orientated and hydrogen bonded to the amide NHs, giving h ighly defined conformations to the molecules; the structure of the val ine derivative (8c) was confirmed by X-ray analysis.