REDOX-ACTIVE METAL-COMPLEXES FOR IMAGING HYPOXIC TISSUES - STRUCTURE-ACTIVITY-RELATIONSHIPS IN COPPER(II) BIS(THIOSEMICARBAZONE) COMPLEXES

Authors
DEARLING JLJ LEWIS JS MCCARTHY DW WELCH MJ BLOWER PJ
Citation
Jlj. Dearling et al., REDOX-ACTIVE METAL-COMPLEXES FOR IMAGING HYPOXIC TISSUES - STRUCTURE-ACTIVITY-RELATIONSHIPS IN COPPER(II) BIS(THIOSEMICARBAZONE) COMPLEXES, Chemical communications, (22), 1998, pp. 2531-2532
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
22
Year of publication
1998
Pages
2531 - 2532
Database
ISI
SICI code
1359-7345(1998):22<2531:RMFIHT>2.0.ZU;2-V
Abstract
Reduction potential and lipophilicity of the copper(II) bis(thiosemica rbazone) complexes can be independently controlled by alkylation in th e diketone backbone and the N-termini of the ligand, allowing optimisa tion of radiopharmaceuticals strongly selective for hypoxic tissues.