THE ORIGIN AND MIGRATION OF PRIMORDIAL GERM-CELLS IN THE MOUSE

Citation
M. Bendelstenzel et al., THE ORIGIN AND MIGRATION OF PRIMORDIAL GERM-CELLS IN THE MOUSE, Seminars in cell & developmental biology, 9(4), 1998, pp. 393-400
Citations number
82
Categorie Soggetti
Cell Biology","Developmental Biology
ISSN journal
10849521
Volume
9
Issue
4
Year of publication
1998
Pages
393 - 400
Database
ISI
SICI code
1084-9521(1998)9:4<393:TOAMOP>2.0.ZU;2-8
Abstract
Primordial germ cells (PGCs) are the founders of the gametes. They mig rate from their origin to combine with the somatic component of the go nad. Progenitors in mice have been recognized in the proximal epiblast . When and how these cells are allocated to the germ line has not been elucidated fully. Numerous growth factors have been described which a ffect PGC survival, proliferation and directional control during their migration. The extracellular matrix also may play a role in PGC migra tion, particularly fibronectin and laminin. Once they have arrived at the gonad, PGCs aggregate with one another. The molecules governing th is PGC-PGC interaction have yet to be identified.