M. Bendelstenzel et al., THE ORIGIN AND MIGRATION OF PRIMORDIAL GERM-CELLS IN THE MOUSE, Seminars in cell & developmental biology, 9(4), 1998, pp. 393-400
Primordial germ cells (PGCs) are the founders of the gametes. They mig
rate from their origin to combine with the somatic component of the go
nad. Progenitors in mice have been recognized in the proximal epiblast
. When and how these cells are allocated to the germ line has not been
elucidated fully. Numerous growth factors have been described which a
ffect PGC survival, proliferation and directional control during their
migration. The extracellular matrix also may play a role in PGC migra
tion, particularly fibronectin and laminin. Once they have arrived at
the gonad, PGCs aggregate with one another. The molecules governing th
is PGC-PGC interaction have yet to be identified.